The patient had a long history of common variable immunodeficiency enteropathy, a condition characterized by diarrhea, malabsorption, and duodenal villous atrophy with intraepithelial lymphocytosis; ...

Nearly every aspect of cellular behaviour and properties can be altered by the production of erroneous proteins. This situation holds true for cells of every living organism from the simplest ...

The Glickman lab, in close collaboration with the Shuman lab, is broadly interested in the pathways and regulation of DNA repair in mycobacteria. Our goals in the DNA repair arena are twofold: 1) to ...

In a recent study posted to the bioRxiv * pre-print server, a team of researchers demonstrated multiple site-directed mutagenesis as an efficient, easy, and more economically viable alternative to ...

Evolution is a virus’s secret weapon. The virus can rapidly slip on new disguises to evade our immune systems, and it can become resistant to antiviral drugs. But some scientists are turning the virus ...

Site-directed mutagenesis (SDM) is a commonly used technique for introducing mutations into a gene of interest. Existing techniques for SDM, such as whole plasmid SDM, while effective, are time ...

Site-directed mutagenesis (SDM) has been an important feature of the research landscape since its introduction in 1995. Continuing improvements to Pfu DNA polymerase have led to enhancements in the ...

Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help ...

The European Court of Justice (ECJ) has ruled on the so-called new plant breeding techniques (NPBTs). It said crops obtained by mutagenesis are GMOs as the techniques and methods of mutagenesis alter ...