Imagine trying to design a key for a lock that is constantly changing its shape. That is the exact challenge we face in ...

Different DNA Structures Nucleate the Folding of Proteins to form specific complexes that modulate the readout of ...

This Collection invites submissions which advance our understanding of the mechanisms of protein misfolding and clearance, and interventions directed at reducing protein aggregates. Quaternery ...

Artificial intelligence has solved one of biology’s most stubborn mysteries: how proteins fold into their intricate three-dimensional shapes. But as the field shifts from prediction to application, a ...

Inspired by the simple mechanism of a seesaw—when one side goes up, the other side goes down—researchers asked an intriguing ...

An AI approach developed by researchers from the University of Sheffield and AstraZeneca, could make it easier to design proteins needed for new treatments. In a study published in the journal Nature ...

A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability In a recent study published in Nature, researchers used ...

A protein’s life is anything but simple. Discover how transcription, translation, folding, modification, and degradation work together to preserve proteome integrity.

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20^100 possible variants-more combinations than atoms in the observable universe.

Edited by: James Kling K.A. Dill, S. Bromberg, K.Z. Yue, K.M. Fiebig, D.P. Yee, P.D. Thomas, H.S. Chan, "Principles of protein-folding-a perspective from simple exact ...