Memorial Sloan Kettering Cancer Center investigators and collaborators have tested rezatapopt, an oral p53 reactivator ...

Proteins that are frequently altered in tumors play a prominent role in cancer research. The protein RFX7, a largely unknown transcription factor, has recently been linked to lymph node cancer.

The gene p53 acts as a tumor suppressor and often is called the ‘guardian of the genome.’ This gene is central to maintaining genomic stability, which prevents mutations from accumulating and leading ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in ...

Molecular basis for JAK2 inhibition with type II compounds. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A Global Summit for Oncology Innovators. This abstract does not include a full ...

The normal function of the p53 tumor suppressor protein is inactivated by different mutations in the TP53 gene in about half of all cancer cases, with Y220C being one the most frequent TP53 missense ...

Kretek cigarettes consist of tobacco, cloves, and sauce, with filtered kretek cigarettes having a filter at one end. Cigarette smoke can harm the respiratory system, so it's important to understand ...

The results of research headed by a team in the lab of Michael Sigal, MD, at the Max Delbrück Center and Charité—Universitätsmedizin Berlin, have shed new light on the role of the p53 tumor suppressor ...